ELISA RUNX1 (Ab-435) anti-

Quantity :100µL Clone Number: Aliases:Acute myeloid leukemia 1 antibody; Acute myeloid leukemia 1 protein antibody; alpha subunit core binding factor antibody; AmL 1 antibody; AmL1 antibody; AmL1 EVI 1 antibody; AmL1 EVI 1 fusion protein antibody; AmL1 oncogene antibody; AmLCR 1 antibody; AmLCR1 antibody; CBF alpha 2 antibody; CBF-alpha-2 antibody; CBFA 2 antibody; CBFA2 antibody; Core binding factor alpha 2 subunit antibody; Core binding factor runt domain alpha subunit 2 antibody; Core-binding factor subunit alpha-2 antibody; EVI 1 antibody; EVI1 antibody; HGNC antibody; Oncogene AmL 1 antibody; Oncogene AmL-1 antibody; OTTHUMP00000108696 antibody; OTTHUMP00000108697 antibody; OTTHUMP00000108699 antibody; OTTHUMP00000108700 antibody; OTTHUMP00000108702 antibody; PEA2 alpha B antibody; PEA2-alpha B antibody; PEBP2 alpha B antibody; PEBP2-alpha B antibody; PEBP2A2 antibody; PEBP2aB antibody; Polyomavirus enhancer binding protein 2 alpha B subunit antibody; Polyomavirus enhancer-binding protein 2 alpha B subunit antibody; Run1 antibody; Runt related transcription factor 1 antibody; Runt-related transcription factor 1 antibody; RUNX 1 antibody; Runx1 antibody; RUNX1_ antibody; SL3 3 enhancer factor 1 alpha B subunit antibody; SL3-3 enhancer factor 1 alpha B subunit antibody; SL3/AKV core binding factor alpha B subunit antibody; SL3/AKV core-binding factor alpha B subunit antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q01196 Immunogen:SyntheQuantityd non-phosphopeptide derived from AmL1 around the phosphorylation site of serine 435 (S-N-S(p)-P-T). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AmL-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Miyoshi H., Proc. Natl. Acad. Sci. U.S.A. 88:10431-10434(1991). Sacchi N., Genes Chromosomes Cancer 11:226-236(1994). Nucifora G., Blood 81:2728-2734(1993). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RUNX1 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Developmental biology;Stem cells