ELISA NLRP1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CARD 7 antibody; CARD7 antibody; Caspase recruitment domain protein 7 antibody; Caspase recruitment domain-containing protein 7 antibody; CLR17.1 antibody; Death effector filament forming Ced 4 like apoptosis protein antibody; Death effector filament-forming ced-4-like apoptosis protein antibody; DEFCAP antibody; DEFCAP L/S antibody; DKFZp586O1822 antibody; KIAA0926 antibody; LRR and PYD domains-containing protein 1 antibody; NAC alpha/beta/gamma/delta antibody; NAC antibody; NACHT antibody; NACHT leucine rich repeat and PYD containing 1 antibody; NACHT leucine rich repeat and PYD pyrin domain containing 1 antibody; NACHT leucine rich repeat and pyrin domain containing 1 antibody; NACHT LRR and PYD containing protein 1 antibody; NALP 1 antibody; NALP1 antibody; NALP1_ antibody; NLR family pyrin domain containing 1 antibody; NLRP 1 antibody; NLRP1 antibody; NLRP1 protein antibody; Nucleotide binding domain and caspase recruitment domain antibody; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1 antibody; Nucleotide-binding domain and caspase recruitment domain antibody; PP 1044 antibody; PP1044 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9C000 Immunogen:Recombinant NACHT, LRR and PYD domains-containing protein 1 protein (1-146AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellµLar milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimµLate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NLRP1 Research Areas:Cell biology