ELISA RORB anti-

Quantity :50µL Clone Number: Aliases:bA133M9.1 antibody; NR1F2 antibody; Nuclear receptor ROR-beta antibody; Nuclear receptor RZR beta antibody; Nuclear receptor RZR-beta antibody; Nuclear receptor subfamily 1 group F member 2 antibody; OTTHUMP00000021486 antibody; RAR related orphan receptor B antibody; RAR related orphan receptor beta antibody; Retinoic acid binding receptor beta antibody; Retinoid-related orphan receptor-beta antibody; ROR BETA antibody; Rorb antibody; RORB_ antibody; RZR BETA antibody; RZRB antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92753 Immunogen:Recombinant Nuclear receptor ROR-beta protein (1-269AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000 Background:Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5\'-AGGTCA-3\' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. ModµLates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regµLates transcription of OPN1SW. Involved in the regµLation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regµLate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation throµgh the inhibition of RUNX2 transcriptional activity (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RORB Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology; Signal transduction