ELISA DDIT4 anti-

Quantity :50µL Clone Number: Aliases:DDIT4 antibody; DDIT4_ antibody; Dig2 antibody; DNA damage inducible transcript 4 antibody; DNA damage inducible transcript 4 protein antibody; DNA damage-inducible transcript 4 protein antibody; FLJ20500 antibody; HIF 1 responsive protein RTP801 antibody; HIF 1 responsive RTP801 antibody; HIF-1 responsive protein RTP801 antibody; Protein regµLated in development and DNA damage response 1 antibody; REDD-1 antibody; REDD1 antibody; RTP801 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NX09 Immunogen:Fusion protein of DDIT4 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100 Background:REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thoµght to function in the regµLation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregµLation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregµLated at the transcriptional level. REDD-1 negatively regµLates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellµLar cues to FRAP regµLation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DDIT4 Research Areas:Epigenetics and Nuclear Signaling;Cancer?CardiovascµLar;Metabolism