ELISA MDC1 anti-

Quantity :50µg Clone Number: Aliases:Homologue to Drosophila photoreceptor protein calphotin antibody; MDC 1 antibody; Mdc1 antibody; MDC1_ antibody; Mediation of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint protein 1 antibody; NFBD 1 antibody; NFBD1 antibody; Nuclear factor with BRCT domains 1 antibody; Nuclear Factor with BRCT Domains Protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14676 Immunogen:Recombinant Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by \'Ser-139\' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MDC1 Research Areas:Epigenetics and Nuclear Signaling