ELISA ITGB1 (Ab-789) anti-

Quantity :100µL Clone Number: Aliases:beta1 integrin antibody; CD_antigen=CD29 antibody; CD29 antibody; Fibronectin receptor subunit beta antibody; FNRB antibody; Glycoprotein IIa antibody; GP IIa antibody; GPIIA antibody; Integrin beta-1 antibody; Integrin subunit beta 1 antibody; integrin VLA-4 beta subunit antibody; Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody; ITB1_ antibody; ITGB1 antibody; MDF2 antibody; MSK12 antibody; OTTHUMP00000019420 antibody; very late activation protein antibody; Very late activation protein, beta polypeptide antibody; VLA BETA antibody; VLA-4 subunit beta antibody; VLA-BETA antibody; VLAB antibody; VLAbeta antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P05556 Immunogen:SyntheQuantityd non-phosphopeptide derived from Integrin ?1 around the phosphorylation site of threonine 789 (V-T-T(p)-V-V). Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimµLation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resµLting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellµLar viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regµLates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction throµgh the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodµLes. May be involved in up-regµLation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successfµL completion of cytokinesis. Isoform 5:Isoform 5 displaces isoform 1 in striated muscles By similarity.G Santoni, Microbiology, Nov 1994; 140: 2971. Maria J. Calzada, J. Biol. Chem., Oct 2004; 279: 41734 - 41743. Lawrence E. Feldman, Cancer Res., Feb 1991; 51: 1065 - 1070. MF Gurish, J. Immunol., Sep 1992; 149: 1964. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ITGB1 Research Areas:Cancer;Metabolism;Signal transduction