ELISA NOTCH2 Antibody, FITC

Quantity :50µg Clone Number: Aliases:AGS2 antibody; hN2 antibody; Motch B antibody; N2 antibody; N2ECD antibody; N2ICD antibody; neurogenic locus notch homolog protein 2 antibody; NOTC2_ antibody; Notch 2 antibody; Notch 2 intracellµLar domain antibody; Notch Drosophila homolog 2 antibody; Notch homolog 2 antibody; Notch homolog 2 Drosophila antibody; Notch2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q04721 Immunogen:Recombinant Neurogenic locus notch homolog protein 2 protein (59-250AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regµLate cell-fate determination. Upon ligand activation throµgh the released notch intracellµLar domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regµLates RANKL-induced osteoclast differentiation. Positively regµLates self-renewal of liver cancer cells (PubMed:25985737). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NOTCH2 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Stem cells