ELISA KPNA2 anti-

Quantity :50µg Clone Number: Aliases:IMA1_ antibody; Importin alpha 1 antibody; Importin alpha 2 antibody; Importin alpha 2 subunit antibody; Importin alpha P1 antibody; Importin subunit alpha-1 antibody; IPO A1 antibody; IPOA 1 antibody; IPOA1 antibody; Karyopherin alpha 2 antibody; Karyopherin alpha 2 RAG cohort 1 antibody; Karyopherin alpha 2 subunit antibody; Karyopherin subunit alpha-2 antibody; KPNA2 antibody; KPNA2 protein antibody; PendµLin antibody; QIP 2 antibody; QIP2 antibody; RAG cohort 1 antibody; RAG cohort protein 1 antibody; RCH 1 antibody; RCH1 antibody; SRP 1 antibody; SRP1 alpha antibody; SRP1 antibody; SRP1-alpha antibody; SRP1alpha antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P52292 Immunogen:Recombinant Importin subunit alpha-1 protein (2-285AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 throµgh binding to nucleoporin FxFG repeats and the complex is subsequently translocated throµgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thoµght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KPNA2 Research Areas:Immunology; Signal transduction