ELISA HUS1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Checkpoint protein HUS1 antibody; hHUS1 antibody; HUS1 (S. pombe) checkpoint homolog antibody; Hus1 antibody; HUS1 checkpoint homolog (S. pombe) antibody; HUS1 Checkpoint Protein antibody; HUS1 protein antibody; HUS1+ - like protein antibody; HUS1_ antibody; Hydroxyurea-sensitive 1, S. pombe, homolog of antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60921 Immunogen:Recombinant Checkpoint protein HUS1 protein (2-280AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimµLates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HUS1 Research Areas:Epigenetics and Nuclear Signaling