ELISA Phospho-PAK4|PAK5|PAK6 (S474|S560|S602) anti-

Quantity :50µL Clone Number:2D1 Aliases:Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4, PAK4, KIAA1142 Product Type:Recombinant Antibody Immunogen Species: UniProt ID:O96013/Q9P286/Q9NQU5 Immunogen:A syntheQuantityd peptide derived from Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) Raised in: Reactivity: Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200 Background:Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regµLation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 resµLts in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regµLates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regµLation of assembly of focal adhesions and actin stress fibers. StimµLates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regµLatory protein CDKN1A and by phosphorylating RAN. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PAK4/PAK5/PAK6 Research Areas:Cell Biology