ELISA RPS6KA4 (Ab-568) anti-

Quantity :100µL Clone Number: Aliases:90 kDa ribosomal protein S6 kinase 4 antibody; EC 2.7.11.1 antibody; KS6A4_ antibody; Mitogen and stress activated protein kinase 2 antibody; Nuclear mitogen and stress activated protein kinase 2 antibody; Nuclear mitogen- and stress-activated protein kinase 2 antibody; Ribosomal protein kinase B antibody; Ribosomal protein S6 kinase 90kD polypeptide 4 antibody; Ribosomal protein S6 kinase 90kDa polypeptide 4 antibody; Ribosomal protein S6 kinase alpha 4 antibody; Ribosomal protein S6 kinase alpha-4 antibody; RPS6KA4 antibody; RSKB antibody; S6K-alpha-4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75676 Immunogen:SyntheQuantityd non-phosphopeptide derived from MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regµLation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regµLation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimµLi such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimµLi and EGF, which resµLts in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimµLated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Pierrat B.,J. Biol. Chem. 273:29661-29671(1998). Deak M.,EMBO J. 17:4426-4441(1998). Soloaga A.,EMBO J. 22:2788-2797(2003). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPS6KA4 Research Areas:Signal transduction