ELISA NEDD4L Antibody, Biotin

Quantity :50µg Clone Number: Aliases:E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_ antibody; NEDD4 2 antibody; NEDD4 2c antibody; Nedd4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; NEDD4b antibody; NEDD4L antibody; NEDD4La antibody; NEDD4Lb antibody; NEDD4Lc antibody; NEDD4Ld antibody; NEDD4Le antibody; NEDD4Lf antibody; NEDD4Lg antibody; NEDD4Lh antibody; NEDL3 antibody; Neural precursor cell expressed developmentally down regµLated 4 like E3 ubiquitin protein ligase antibody; Neural precursor cell expressed; developmentally down regµLated 4 like antibody; RSP5 antibody; Ubiquitin protein ligase Rsp5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96PU5 Immunogen:Recombinant E3 ubiquitin-protein ligase NEDD4-like protein (289-494AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5 (PubMed:26363003). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regµLation of TOR signaling (PubMed:27694961). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NEDD4L Research Areas:Epigenetics and Nuclear Signaling; Cell biology