ELISA LIN28A anti-

Quantity :100µL Clone Number: Aliases:AL024421 antibody; CSDD1 antibody; CSDD2 antibody; FLJ12457 antibody; Lin 28 antibody; Lin 28 homolog (C. elegans) antibody; Lin 28 homolog A (C. elegans) antibody; Lin 28 homolog A antibody; Lin 28 homolog antibody; Lin-28A antibody; Lin28 antibody; Lin28, C. elegans, homolog of, A antibody; LIN28A antibody; LN28A_ antibody; Protein lin-28 homolog A antibody; Protein lin-28 homolog B antibody; RNA binding protein lin 28 antibody; Tex17 antibody; ZCCHC1 antibody; Zinc finger CCHC domain containing 1 antibody; Zinc finger CCHC domain containing protein 1 antibody; Zinc finger CCHC domain-containing protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H9Z2 Immunogen:Peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Lin28 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs resµLts in an increased number of initiation events per molecµLe of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program throµgh the translational up-regµLation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. Heo I., Joo C., Mol. et al., Cell 32:276-284(2008) Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009) Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LIN28A Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;Developmental biology;Stem cells