ELISA Phospho-NBN (Ser343) anti-

Quantity :100µL Clone Number: Aliases:AT V1 antibody; AT V2 antibody; ATV antibody; Cell cycle regµLatory protein p95 antibody; FLJ10155 antibody; MGC87362 antibody; Nbn antibody; NBN_ antibody; NBS 1 antibody; NBS antibody; NBS1 antibody; Nibrin antibody; Nijmegen breakage syndrome 1 (nibrin) antibody; Nijmegen breakage syndrome antibody; Nijmegen breakage syndrome protein 1 antibody; p95 antibody; p95 protein of the MRE11/RAD50 complex antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60934 Immunogen:Peptide sequence around phosphorylation site of serine 343 (S-L-S(p)-Q-G) derived from p95/NBS1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thoµght to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Hsu HL, et al (2005) Oncogene; 24(31): 4956-64. Falck J, et al. (2005) Nature; 434(7033): 605-11. Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700. Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NBN Research Areas:Epigenetics and Nuclear Signaling;Cancer