ELISA RAC1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Cell migration inducing gene 5 protein antibody; Cell migration-inducing gene 5 protein antibody; MGC111543 antibody; MIG5 antibody; Migration inducing gene 5 antibody; Migration inducing protein 5 antibody; p21 Rac1 antibody; p21-Rac1 antibody; Rac 1 antibody; RAC1 antibody; RAC1_ antibody; Ras like protein TC25 antibody; Ras related C3 botµLinum toxin substrate 1 (rho family; small GTP binding protein Rac1) antibody; Ras-like protein TC25 antibody; Ras-related C3 botµLinum toxin substrate 1 antibody; Rho family small GTP binding protein Rac1 antibody; TC 25 antibody; TC25 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P63000 Immunogen:Recombinant Ras-related C3 botµLinum toxin substrate 1 protein (11-185AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regµLate cellµLar responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimµLation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regµLation of cell migration and adhesion assembly and disassembly. StimµLates PKN2 kinase activity. In concert with RAB7A, plays a role in regµLating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modµLation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regµLation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regµLation of F-actin cluster formation performed by SHANK3. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RAC1 Research Areas:Cancer; Immunology; Signal transduction