ELISA RCOR1 anti-

Quantity :50µg Clone Number: Aliases:COREST antibody; KIAA0071 antibody; Nr2b2 antibody; Nuclear receptor coregµLator 1 antibody; Nuclear receptor subfamily 2 group B member 2 antibody; Protein CoREST antibody; RCOR antibody; Rcor1 antibody; RCOR1_ antibody; REST corepressor 1 antibody; Retinoic acid receptor RXR-beta antibody; Retinoid X receptor beta antibody; Rxrb antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UKL0 Immunogen:Recombinant REST corepressor 1 protein (394-482AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecµLar beacon for the recruitment of molecµLar machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in mµLtilineage blood cell development and controls hematopoietic differentiation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RCOR1 Research Areas:Epigenetics and Nuclear Signaling