ELISA Recombinant Noggin protein(NOG) (Active)

Quantity:100µg. Research Areas:Stem Cells Uniprot NO.:Q13253 Uniprot Entry Name:NOGG_ Gene Names:NOG Species:Homo sapiens () Source:E.Coli Expression Region:M+28-232aa Sequence:M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:23.2 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/mL, corresponding to a specific activity of ? 3.3 × 105 IU/mg in the presence of 5 ng/mL rHuBMP-4. Purity:>95% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias: Relevance:Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation throµgh its interaction with GDF5 (PubMed:21976273). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}. PubMed ID:7666191; 15489334; 21976273; 24098149; 12478285; 10080184; 11846737; 11545688; 12089654; 11857750; 15770128; 17668388; 20503332 Function:Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation throµgh its interaction with GDF5 and, probably, GDF6 Involvement in disease:Symphalangism, proximal 1A (SYM1A); MµLtiple synostoses syndrome 1 (SYNS1); Tarsal-carpal coalition syndrome (TCC); Stapes ankylosis with broad thumb and toes (SABTS); Brachydactyly B2 (BDB2) SubcellµLar Location:Secreted Protein Families:Noggin family Tissue Specificity: Paythway:TGF-betasignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:7866 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=248201 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:9241 STRING Database Link:https://string-db.org/network/9606.ENSP00000328181 OMIM Database Link:https://www.omim.org/entry/184460184460184460