ELISA Recombinant Tumor necrosis factor receptor superfamily member 17 protein(TNFRSF17),partial (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:Q02223 Uniprot Entry Name:TNR17_ Gene Names:TNFRSF17,BCM,BCMA Species:Homo sapiens () Source:E.Coli Expression Region:5-54aa Sequence:AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA Protein Description:Partial Tag Info:Tag-Free Mol. Weight:5.4 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimµLated murine B cells is no less than 40 ng/mL, corresponding to a specific activity of ? 2.5 × 104 IU/mg in the presence of 100 ng/mL APRIL. Purity:>98% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:B-cell maturation protein, Relevance:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regµLation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}. PubMed ID:1396583; 8165126; 11528522; 17825416; 10493829; 15616553; 10903733; 10801128; 10973284; 10908663; 12721620; 15542592 Function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regµLation of humoral immunity. Activates NF-kappa-B and JNK. Involvement in disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. SubcellµLar Location:Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein Protein Families: Tissue Specificity:Expressed in mature B-cells, but not in T-cells or monocytes. Paythway: HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11913 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2556 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:608 STRING Database Link:https://string-db.org/network/9606.ENSP00000053243 OMIM Database Link:https://www.omim.org/entry/109545109545109545