ELISA Recombinant Interleukin-1 alpha protein(IL1A) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:P01583 Uniprot Entry Name:IL1A_ Gene Names:IL1A,IL1F1 Species:Homo sapiens () Source:E.Coli Expression Region:113-271aa Sequence:SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:18.0 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/mL, corresponding to a specific activity of ? 1.0 × 109 IU/mg. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-1 alpha, Relevance:Produced by activated macrophages, IL-1 stimµLates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimµLate the release of prostaglandin and collagenase from synovial cells. PubMed ID:2989698; 3486405; 2994016; 2635664; 3485152; 3493774; 11991722; 14702039; 15815621; 15489334; 3281727; 8346241; 2346741 Function:Produced by activated macrophages, IL-1 stimµLates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimµLate the release of prostaglandin and collagenase from synovial cells. Involvement in disease: SubcellµLar Location:Secreted Protein Families:IL-1 family Tissue Specificity: Paythway:MAPKsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5991 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=1722 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3552 STRING Database Link:https://string-db.org/network/9606.ENSP00000263339 OMIM Database Link:https://www.omim.org/entry/147760147760147760